The Spike glycoprotein reseptor-binding domain (RBD) ee SARS-CoV-2 waxay dhexdhexaadinaysaa xuubabka fayrasku ku xidho angiotensin-converting enzyme 2 (ACE2) receptor dusha unugyada aadanaha.Sidaa darteed, is dhexgalka Spike-ACE2 waa arrin muhiim ah oo lagu go'aamiyo infekshannada fayraska. Koox cusub oo phylogenetic ah oo ah SARS-CoV-2 (lineage B.1.1.7), kaas oo muujinaya beddelka amino acid ee Spike RBD (N501Y mutation).
Marka loo eego cilmi-baarista cusub ee Waaxda Caafimaadka ee Boqortooyada Ingiriiska, oo ku saleysan xogta taxanaha hiddo-wadaha, cudurrada faafa iyo qaabeynta, infekshanka noocyada kala duwan ee SARS-CoV-2 ayaa ku dhawaad 40-70% ka sarreeya saynisyahannada wax ka beddelka ee kale ee la aqoonsan yahay. .Jawaabta degdega ah iyo ogaanshaha waa mid ka mid ah cabbirka ka hortagga iyo xakamaynta muhiimka ah.
Xirmada waxaa loo isticmaalaa in lagu ogaado tayada tayada leh ee ORF1ab/N/S hiddo-wadaha coronavirus 2019-nCoV ee shaybaarka neefsiga, iyo samaynta isku-dheellitirka qorista N501Y.
Qalabku wuxuu qaataa habka ARMS, wuxuu qaataa hidda-wadaha S ee novel coronavirus (2019-nCoV) inuu yahay gobolka bartilmaameedka u ah qorista beddelka, wuxuu naqshadeeyaa furayaasha gaarka ah iyo baaritaannada N501Y.
| Alaabta | Tilmaamaha | Heerkulka kaydka | Sharaxaada |
| Qalabka PCR ee wakhtiga dhabta ah ee NovelCoronavirus 2019-nCoV iyoNovel Coronavirus 2019-nCoVIsbeddelka Hiddaha (N501Y) | 48T | -20℃ | Falanqaynta: Nooca duurjoogta ah ee N501Y,Nooca Mutant ee N501Y, ORF1ab,N hidda-socodka iyo xakamaynta gudaha |
Waafaqsanaanta qaab-dhismeedka
- Oropharyngeal Swabs
- Nasopharyngeal suuf
- Dheecaan Lavage Bronchoalveolar
- xaako
Qaybaha Kit
- Dib-u-celinta falcelinta RT-PCR
- Isku darka enzyme RT-PCR
- Xakamaynta togan ee nooca duurjoogta ah
- Isbeddelka xakamaynta togan
- Xakamaynta xun
Nooca isku beddelka N501Y
